Marijuana Ingredient Kills Rat Brain Tumors 

Marijuana Ingredient Kills Rat Brain Tumors 
Posted by FoM on February 28, 2000 at 21:12:07 PT
Not known whether approach would work in people 
Source: MSNBC
Marijuana-like drugs eradicated some brain cancers in rats and helped other animals live longer, possibly hinting at a new approach for treating the disease, researchers say. But brain cancer experts said they aren’t impressed.     The study dealt with gliomas, the most common category of cancer arising in the brain. Gliomas are highly lethal in people despite treatment with drugs, surgery and radiation.
Research To Begin on ‘Pot Patch’ Post your views on MSNBC's Health Bulletin Board    The rat study was published in the March issue of the journal Nature Medicine. It was conducted by scientists at the Complutense and Autonoma universities in Madrid, Spain.    Marijuana, or cannabis, is best known for its ability to give people a “high,” but the plant also has medicinal properties, such as relieving pain and nausea.    Study Details:    The researchers injected glioma cells into the brains of rats to produce tumors. Untreated rats died within 18 days.    Other rats were treated with drug infusions for seven days through a tube leading to the tumor. Fifteen rats got infusions of THC, the main active component in marijuana. Tumors disappeared in three animals, and nine other rats outlived the untreated ones, surviving up to 35 days.    When researchers used a different but similar drug, five of 15 rats became tumor-free and four others outlived untreated animals, the researchers said.    The scientists said they did not know if the cancer treatment was appropriate for humans, but they planned further studies. Cancer treatments that work in animals may be too toxic or not effective in humans.    The chemicals activated two receptors, or chemical doorways to cells, which prompted an increase in a lipid known as ceramide. The researchers theorized that ceramide in turn activated a chain of protein reactions that killed the cancerous cells.    One of the researchers, Dr. Manuel Guzman, said in an interview he hoped to start human tests in about a year. “We are quite happy with (the findings), and we believe we can at least try and see what happens in humans,” Guzman said.    Waiting To Inhale: Hemp for Health?    Dr. Daniele Piomelli of the University of California at Irvine wrote in separate article the rat findings were encouraging, given the bleak scenario for treating malignant gliomas.    Patients usually receive surgery, radiation and chemotherapy, but median survival is 40 to 50 weeks.    “Although incomplete, these findings must be seriously considered,” Piomelli wrote.    Much More research Needed:      But Dr. Philip Gutin, chief of neurosurgery at the Memorial Sloan-Kettering Cancer Center in New York, said other experimental therapies work better in rats. And the paper doesn’t demonstrate that the effect came from the drugs rather than simply the infusion of liquid into the brain, he said.    Dr. Rolf Barth, who studies brain tumors at Ohio State University, called the work interesting. But he said the type of glioma cells used to create the tumors does not provide a very good mimic of the human disease.    Published: February 28, 2000    The Associated Press and Reuters contributed to this report.MSNBC POLL: Medical Marijuana: Should It Be Legal? Articles:Marijuana Ingredient May Fight Brain Cancer Medical Marijuana Archives:
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Comment #4 posted by CongressmanSuet on February 29, 2000 at 23:39:05 PT
Thanks for the link...
   As much as I love Bob, I never got around to hitting the site, thanks for the link.
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Comment #3 posted by ReggaeLover on February 29, 2000 at 15:19:30 PT
Me don't know mon, me hear dat CIA gave Bob Marley cancer in him toe. But you 'ear dem tings.
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Comment #2 posted by CongressmanSuet on February 29, 2000 at 14:29:44 PT
 Yes, and on the same note....
   Didnt Bob Marley die from brain cancer? So maybe smoking might not be the ideal application in this particular instance. Although I personally dont think it can hurt.
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Comment #1 posted by ReggaeLover on February 29, 2000 at 13:14:19 PT
Sugar Minot was Right!
"De doctor say it good for me cancer."  -- Sugar Minot, Herbman Hustling (1984)Ha! Sugar Minot was right after all !
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