The Ecstasy Factor

The Ecstasy Factor
Posted by CN Staff on March 09, 2004 at 10:29:06 PT
By Carla Spartos
Source: Village Voice
Today is different: You're speaking to a psychiatrist—not in a sterile, fluorescent-lit hospital, but in a residential office on a peaceful, tree-lined street. You suffer from post-traumatic stress disorder, and you've talked for hours in this very room, but always skipping the violent chapter that keeps you up at night, giving you flashbacks and causing you to feel estranged from your loved ones. Now an emergency room doctor and nurse are stationed inside the house. You've brought an overnight bag. Today, you've been given 125 milligrams of Ecstasy, and maybe, just maybe, you'll finally be able to face your demons.
On February 24, the DEA issued Dr. Michael Mithoefer a Schedule I license to legally obtain Ecstasy for a study of its potential therapeutic effects in the treatment of PTSD. Researchers hope that the drug, which melts anxiety, will help PTSD patients talk openly about the experiences that scarred them. It is the first study of Ecstasy-enhanced psychotherapy ever green-lighted in the United States, one that's been in the making for almost two decades. "There's been so much struggle over this approval process," says Rick Doblin, director of MAPS, the Multidisciplinary Association for Psychedelic Studies, the organization sponsoring the research. Doblin's group stands to create a new landscape for Ecstasy, which has been at the center of the nation's war on drugs. The old one—with its hidden agendas, career-obsessed scientists, powerful patrons, and switched pills—has only recently been scorched. It all began in September, when the journal Science published a retraction from a group of Johns Hopkins scientists who'd discovered that a bottle they thought contained Ecstasy was in fact filled with methamphetamine, commonly known as speed. The mix-up corrupted the results of a study, published in Science in September 2002, which found that a single, recreational dose of Ecstasy was so damaging it could lead to Parkinson's disease. Another study, published in the European Journal of Pharmacology, would also be recalled. The British journal Nature promptly published an editorial dubbing the incident "one of the more bizarre episodes in the history of drug research." Colin Blakemore, head of the U.K.'s Medical Research Council (the British equivalent of the National Institutes of Health), demanded that an independent inquiry be conducted into the affair. And The New York Times' Donald G. McNeil Jr. wrote a scathing indictment of the study's lead scientist, George Ricaurte, alleging "a pattern of shaky research supporting alarmist press releases." Ricaurte did not respond to repeated messages left on his voice mail at Johns Hopkins or to an official request through Johns Hopkins representatives, but he has long been dismissive of his work's critics. In 2001, he told the Voice, "Everyone in the field has accepted [MDMA] is a neurotoxin. I think those [dissenting] arguments have to be put in perspective." It is this unyielding conviction that has been the hallmark of Ricaurte's career as the nation's foremost Ecstasy researcher. But critics say the science has been less than convincing. Ecstasy promotes strong feelings of empathy by flooding the brain with serotonin, a feel-good neurotransmitter manipulated by drugs like Prozac. Once the high wears off, users register markedly depleted serotonin levels for about two weeks. What is not known—and thus is hotly debated—is whether these changes presage permanent brain damage. That debate seemed settled when Science issued a press release in September 2002 announcing the devastating results of Ricaurte's study: After taking doses of Ecstasy akin to what teens might take at a rave, 60 to 80 percent of dopamine-related neurons in the test monkeys' brains were destroyed. The release was picked up in headlines around the globe. But some of those who got around to reading the actual study say what they found troubled them. "The press release deliberately misrepresented the data," says Colin Blakemore. "There was no evidence of the 60 to 80 percent cell-death claim." There were other red flags: 20 percent of the monkeys had died; another 20 percent had gotten so sick they had to be withdrawn. Yet there simply aren't thousands of people dying from Ecstasy every weekend. Then there was the problem that the drugs were injected—not administered orally as suggested in the paper's introduction. "The more I looked at it, the more I felt there was an agenda," says Blakemore, who immediately fired off a letter to Science editor in chief Donald Kennedy, complaining of "flaws so radical, so deep, they would have been picked up by any referee." But Science maintains it did everything right. "This study was peer-reviewed according to the same rigorous system used in all articles published in Science," says Ginger Pinholster, spokesperson for the Association for the Advancement of Science, which publishes the journal. According to Pinholster, the prompt retraction proved that "science is self-correcting." Public policy, however, is not so mutable. Weeks after the botched study was published, its conclusions were repeatedly invoked by witnesses at a House subcommittee hearing on the Reducing Americans' Vulnerability to Ecstasy Act (RAVE Act). The bill was quietly passed last April as the slightly reworded Illicit Drug Anti-Proliferation Act. Aimed at quelling club drugs like Ecstasy and GHB, the law permits the prosecution of venue owners and club promoters for drug use on their premises. Only a month after it became law, it was used by a federal agent to shut down a benefit for Students for Sensible Drug Policy and the National Organization for the Reform of Marijuana Laws. And last weekend, it was used to shutter the Sound Factory nightclub in Manhattan. As easy as it is to paint Ricaurte as a rogue scientist motivated by ambition, the scientific establishment and its patrons also played key roles in the wider scandal, from merely ignoring critical flaws to blatantly promoting problematic studies. Alan Leshner, publisher of Science and former director of the National Institute on Drug Abuse (NIDA), has come under fire for endorsing the botched study at its time of publication. "It isn't clear why an officer of the AAAS should be involved at all in publicly promoting a particular result published in its journal, least of all one whose outcome was questioned at the outset by several experts," wrote Nature. Pinholster says she called upon her boss "to serve as an expert source as a service to reporters," adding, "There was no conspiracy." Leshner declined to be interviewed. Leshner has long railed against the dangers of Ecstasy. In 2001, when he was director of NIDA, he told the Voice, "We've known since the late '80s that MDMA can damage serotonin neurons, and if you give enough of it, they're blown away." Rick Doblin, on the eve of his own study, says the payoffs for such shoddy science have been immense. "Leshner was willing to exaggerate findings to pander to politicians for money," he says. Leshner did help NIDA bring home the bacon: NIDA's budget for Ecstasy research has more than quadrupled over the past five years, from $3.4 million to $15.8 million; the agency funds 85 percent of the world's drug-abuse research. In 2001, Leshner testified before a Senate subcommittee on "Ecstasy Abuse and Control"; critics say Leshner manipulated brain scans from a 2000 study by Dr. Linda Chang showing no difference between Ecstasy users and control subjects. But NIDA insists it's independent from political pressures. "We don't set policy; we don't create laws," says Beverly Jackson, the agency's spokesperson. NIDA wasn't the only benefactor of Ricaurte and wife Una McCann's research. "George and Una are cash cows for Johns Hopkins," says Doblin, who points out that every time a scientist receives a grant, money indirectly goes to the affiliated institution. While both NIDA and The New York Times have clocked Ricaurte's NIDA grant money at around $10 million, Doblin believes that's a low-ball figure. "Just this one study was $1.3 million, and he has done loads and loads of them." Johns Hopkins spokesperson Gary Stevenson declined comment beyond the official statement. Another consequence of the retracted study and other discredited NIDA-funded findings is that they've helped obstruct legitimate research into the possible medical benefits of Ecstasy. Doblin believes Ricaurte and others are threatened by such research because it doesn't square with their drug-war agenda. In the past, Leshner has balked at those accusations. "It frankly bugs me," he told the Voice in 2001. "It's easy to say that the government isn't approving studies because they're politically incorrect. The government may say yes." ´ Now that the government—more specifically, the FDA—has indeed said yes, Doblin's research into the benefits of Ecstasy in treating post-traumatic stress disorder is under way. The $300,000 MAPS project, which is funded by private individuals and family foundations, has had some major setbacks since it initially received FDA approval in November 2001. The study was to have been conducted at the Medical University of South Carolina before that institution backed out; it will now be held in a private doctor's office. While Doblin believes the program would have gotten off the ground without Ricaurte's retraction, he says it's made all the players, including the institutional review board and insurance company, "feel a lot more comfortable." A study under way in Spain examining the potential therapeutic effects of Ecstasy in rape victims hasn't fared as well. The Madrid Anti-Drug Authority pressured the sponsoring hospital to shut the study down in May 2002. Doblin largely blames Ricaurte for the mounting difficulties the research team has faced since then: Ricaurte, who was born in Ecuador, is fluent in Spanish, and gave four talks in Spain presenting his bungled findings. As for the Illicit Drug Anti-Proliferation Act, Margaret Aitken, press secretary for Senator Joseph Biden, who sponsored the bill, said, "Senator Biden will not change his position based on this one [retracted] study." A Senate aide also confirmed the legislation would not be revisited, and that there's "no official process to go back and correct the record." Blakemore, meanwhile, is still calling for a "full and open discussion" from Science, including the disclosure of the paper's referee reports. "If the referees didn't spot what I noticed right away, then what does that say about the quality of [Science's] referees?" asks Blakemore. "And if the referees did make negative comments [that went unheeded], what does that say about Science?" At press time, Blakemore and Leslie Iversen, an Oxford University pharmacologist, were drafting a letter that Don Kennedy has promised to publish in Science. That journal, NIDA, and Johns Hopkins insist there's been no evidence of foul play; no investigations were being conducted at any of these institutions at press time. In the end, the ones most negatively affected by the studies may be those they purport to help. "I'm very concerned about drug use, but the way to tackle it is not to misrepresent scientific evidence," says Blakemore. "What's going to be the impact of these studies? Young people won't believe anything they read." Note: Bad Science Slandered a Generation's Favorite Drug. Now a New Study Aims to Undo the Damage.Source: Village Voice (NY)Author: Carla SpartosPublished: March 10 - 16, 2004Copyright: 2004 VV Publishing CorporationContact: editor villagevoice.comWebsite: Articles & Web Sites:MAPS Agonistes Approves Trial Of Ecstasy in Trauma Cases On Ecstasy Is Clouded By Errors Will Kill You -- Wait, No It Won't
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Comment #10 posted by FoM on April 07, 2004 at 12:44:00 PT
Thanks afterburner
I appreciate the updates. I hope he doing ok. I know they've put restrictions on him and that must be hard for him.
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Comment #9 posted by afterburner on April 07, 2004 at 12:40:32 PT:
Another Missing Link
Marc Emery Out Of Jail! Marc's own words about his three night Saskatoon jail ordeal.
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Comment #8 posted by afterburner on April 07, 2004 at 12:19:13 PT:
FoM, I Just Found this Update on Marc
Marijuana advocate back in court - CBC Saskatchewan
"... with trafficking marijuana. Two weeks ago, Marc Emery was speaking to university
students about the movement to decriminalize the plant. He was arrested later ..." 
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Comment #7 posted by afterburner on April 07, 2004 at 09:49:50 PT:
D'oh, I Forgot the Link
Ecstasy Rising link Marc Emery:I haven't seen him for several weeks, since before the Saskatoon bust. He did post on CC Forum yesterday, and the following clip was recorded after his release on bail, but before last Wednesday's court appearance in Saskatoon:Marc Emery Out Of Jail!
Prince of Pot with Pot-TV 
Running Time: 20 min 
Date Entered: 26 Mar 2004  
 "After a visit at Club Fed in Saskatoon, Marc recounts his court experience, bail conditions and outrageous allegations all for two joints!"The media has been strangely quiet on the disposition of this case. Stay tuned.
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Comment #6 posted by FoM on April 07, 2004 at 09:40:00 PT
News Article About Ecstasy Rising from ABC News
House Anti-Narcotics Chairman Reacts Strongly to Ecstasy Promotion by ABC, JenningsBy Jimmy Moore, Talon NewsApril 6, 2004Rep. Mark Souder (R-IN), the House anti-narcotics chairman, reacted strongly to the reporting on an illegal drug by ABC News anchorman Peter Jennings.Souder responded to comments he read in the Palm Beach Post by Jennings last week regarding the popular mind-altering drug Ecstasy.Jennings said he was concerned that claims by the U.S. government that Ecstasy is unsafe are exaggerated, causing young people to question any information provided in the future."Government is best when government is most honest, especially for the younger generation, which is more susceptible to trying drugs," Jennings remarked to the Palm Beach Post. "If they can't rely on the government for good and honest information, then government has lost something enormously valuable, which is people's belief in the government's credibility."In a one-hour news special that aired last Thursday called "Peter Jennings Reporting: Ecstasy Rising," Jennings examined the government's futile record for slowing the distribution of the pills."This was an opportunity for us to look at whether or not the government isn't its own worst enemy in trying to control illegal drugs," Jennings explained to the Palm Beach Post regarding the show.Promoting the benefits of Ecstasy rather than the dangers in his show, Jennings said he is not concerned at all that this will pique the interest of young people to try the illegal drug."It can't be a concern," Jennings said regarding young people wanting to try Ecstasy. "Our job is to lay out the facts."Souder said he could not believe a well-known news anchor like Jennings would make such comments about a drug that has been banned in the United States since 1985."I'm outraged by the irresponsible comments that [Jennings] made in advance of its airing," Souder exclaimed. "Their appalling nature does not leave me optimistic about the veracity and good intentions of the 'production' he's touting."Using his experience dealing with anti-narcotics issues in Congress, Souder said the research conducted by Jennings and ABC is severely flawed."Jennings exposes a great deal about his own selective research methods when he claims that the government's 'science was not good,'" Souder states. "Countless studies have proven that Ecstasy is far from a benign drug."He added, "Reams of evidence demonstrate that Ecstasy causes brain damage and even death."As for the carefree manner that Jennings conducted this program, Souder said the lack of a moral compass by the ABC news anchor is especially disturbing."If Jennings' nonchalant comments about this dangerous drug are indicative of the outlook of his 'special,' then he is misleading his viewers," Souder remarked. "To make matters worse, Jennings appears to have no moral qualms about offering the American public what the Palm Beach Post cast as 'a glossy, late-night infomercial.'"Questioning the motives of Jennings' reporting of this story, Souder said Jennings needed to look into the subject further."Jennings somehow believes that his take on Ecstasy is tantamount to 'laying out the facts.' But how much does Jennings actually know about the facts?," Souder commented.Providing an example of how Ecstasy has caused harm, Souder challenged Jennings to show the whole truth about the negative effects of Ecstasy to complete his story."In 2002, I heard testimony from the mother of 23-year-old Kelley Baker who died of an Ecstasy overdose," Souder noted. "Will Jennings' 'special' offer the facts about Ecstasy's effects on her young life?"
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Comment #5 posted by FoM on April 07, 2004 at 08:24:46 PT
Do you have a link to the show? I was busy when it was on and missed it. I should have time tonight to watch it. Thanks!PS: How is Marc holding up?
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Comment #4 posted by afterburner on April 07, 2004 at 06:58:31 PT:
Ecstasy Rising
Now available on Pot-TV for those of you who missed it:
Stoner Show: ABC Special, Ecstasy Rising Stoner Show with Pot-TV Running Time: 42 min Date Entered: 06 Apr 2004 "Big James sent in this copy of the recent ABC special, Ecstasy Rising." Use of Ecstasy by psychotherapists for PTSD was legal before the DEA freaked out and added E to Schedule One. Another interesting DEA comment opines that legal Ecstasy threatened Prohibition!
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Comment #3 posted by E_Johnson on March 09, 2004 at 23:48:23 PT
How nice to see Alan Leshner in disgrace
Hip hip hooray
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Comment #2 posted by afterburner on March 09, 2004 at 16:02:19 PT:
Do You Trust a Gatekeeper w/ Drug Abuse in Name? 
'After Two-Decade Halt, Marijuana Research Is Set December 14, 2001: 'One of the two studies already approved will concern multiple sclerosis patients. Some of those patients say they have muscle rigidity that is not relieved effectively by other drugs, and in any case those drugs have unwanted side effects. Dr. Jody Corey-Bloom, who will lead this study, at the University of California at San Diego, cites anecdotal accounts that marijuana can relieve that muscle pain and rigidity.'In the other approved study, also at the San Diego campus, Dr. Ronald Ellis will try to determine whether marijuana can relieve a kind of pain in the hands and feet, known as peripheral neuropathy, that sometimes affects H.I.V. patients.'Dr. Donald Abrams will also study that condition at the University of California at San Francisco, in the experiment due for final approval soon....'The coming experiments [2001] will compare the effects of marijuana cigarettes with the effects of placebo cigarettes (those with the active ingredients of marijuana removed).'The marijuana cigarettes will come from a supply grown at the University of Mississippi under the auspices of the National Institute on Drug Abuse'--After Two-Decade Halt, Marijuana Research Is Set December 14, 2001 controls cannabis, like Fort Knox control gold. Cannabis is not gold, but due to the NIDA monopoly and the black market resulting from prohibition, cannabis is as valuable as gold. Please don't try smoking gold unless it's Acapulco or Kona.
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Comment #1 posted by kaptinemo on March 09, 2004 at 12:14:46 PT:
Burn their *sses with it, MAPS!
This raging Lysenkoism of using intellectually dishonest studies to justify Draconian government policies has to come to an end someday, and this is the perfect start. Too many scientists taking the government's dollars have been engaging in pimping themselves for profit, to the point of falsifying data in studies paid for by the taxpayer and using those studies to garner even greater influence and funding with their government 'patrons'.Lysenko set back Soviet biological sciences decades because of his politically blessed 'research' - sanctioned by Stalin - was just as half-cocked as Ricaurte's. Evidently, some American scientists are willing to turn a blind eye to corruption and intellectual dishonesty - or engage in it - as the old Sov's were *forced* to. But there's one major difference: the Sovs *had* no choice, whereas these scientific whores most certainly do.
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