Endocannabinoids – The Brain's Cannabis 

  Endocannabinoids – The Brain's Cannabis 

Posted by CN Staff on July 18, 2005 at 22:24:59 PT
For Immediate Release 
Source: EurekAlert 

 Three Teams Point To Possible Applications in Satiety, Disease, BehaviorSteamboat Springs, Colorado -- Three separate research team reports – one from Louisiana, one from Japan and one from Scotland – are presenting independent research results pointing to involvement of endocannabinoids as a novel neural messenger in various stress-related situations with possible applications in eating, disease treatment and social behavior.
Tulane, LSU Team on Stress-Related Shutdown The team from Tulane and Louisiana State Universities, led by Shi Di, found that in both physiological and psychological stress situations, stress hormones act on the brain to stimulate the release of endogenous cannabinoids from neurons in the hypothalamus, which act as a local messenger within the hypothalamus to shut down the neuroendocrine stress response. One explanation for this hormone feedback regulation of the stress response might be to prepare the brain to mount another response in case of the onset of another possible stressor. The endogenous cannabinoids may serve to link the stress response with other neuroendocrine functions controlled by the hypothalamus, such as feeding. Di says that the "actions of the endocannabinoids on the synaptic circuits that control the activity of the hypothalamic neurons serve to rapidly inhibit hormone secretion from the pituitary gland, providing a rapid negative feedback mechanism for the regulation of neuroendocrine function during stress."  Japanese Team Finds Inhibition of Excitatory and Inhibitory Synaptic TransmissionIn an in vitro study, a multi-center Japanese team led by Atsushi Soya focused on the supraoptic nucleus (SON) where vasopressin and oxytocin are synthesized. They found that a synthesized cannbinoid (CP55,940) inhibited both excitatory and inhibitory synaptic transmission and that a balanced input can produce sustained changes in neuronal activity without damage to neuronal homeostasis. "Our next step is to investigate cannabinoids' effects in various stress conditions," Soya said. "Endocannabinoids may have possible involvement in stress-induced responses such as the changes of autonomic, endocrine and immune function." Furthermore, Soya added, "cannabinoids are relevant to potential relief in such disease situations in the brain as multiple sclerosis and epilepsy, or feeding disorders. In these, their effects are similar to marijuana, except for the possible dangers of accidentally using the natural products at higher dosages." Scottish Team Seeks Social behavior AnswersNancy Sabatier of the University of Edinburgh, noted that "cannabis, or marijuana, is a drug that is widely abused because of the effects it can have on our mood and our social behavior. Cannabis works this way because it acts like substances that are produced inside our brains that are messengers between brain cells. Our work involves trying to understand what these substances, endocannabinoids, are for." She said they are particularly interested in how endocannabinoids influence oxytocin cells in the brain, because because OT within the brain is involved in social behavior. "We have found that oxytocin cells produce endocannabinoids, and can release these to switch off other inputs to the oxytocin cells themselves. We are looking at what stimuli will cause oxytocin cells to release endocannabinoids to understand why this system might be important." Sabatier noted that most related experiments are carried out in rats, "but we think that the basic ways in which these circuits work is very similar in all mammals. These brain circuits are very old in evolutionary terms, and they govern behaviors that are of fundamental importance to most species." Editors note: Di, Soya and Sabatier are presenting each of their team's research at the American Physiological Society's 2005 Conference, "Neurohypophyseal Hormones: From Genomics and Physiology to Disease," plus the latest developments toward clinical applications, July 16-20 in Steamboat Springs, Colorado. In addition, Shi Di is participating in the symposium, "Pressure/volume regulation of VP/OT release," chaired by Tom Cunningham of the University of Texas Health Science Center, and Leo Renaud of the Ottawa Health Research Center, Canada. Shi Di, Victor Marcheselli, Nicolas Bazan, Jeffrey Tasker. Di and Tasker are at the Neurobiology Division and Cell & Molecular Biology Department at Tulane University, New Orleans; Tasker is also at the Neuroscience Program; Marcheselli and Bazan are at the Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans. "Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and GABA inputs to hypothalamic magnocellular neurons." Funded by NIH. Atsushi Soya, Ryota Serino, Tatsushi Onaka, Takeshi Terao, Jun Nakamura, Yoichi Ueta. Soya and Ueta are at Dept. of Physiology School of Medicine, University of Occupational & Environmental Health (UOEH), Kitakyushu; Serino is at the UOEH Dept. of Internal Medicine; Onaka is at Division of Integrative Physiology, Dept. of Physiology, Jichi Medical School; Terao is at Dept. of Psychiatry, Oita University School of Medicine; and Nakaura is at UOEH Dept. of Psychiatry. Nancy Sabatier, Gareth Leng, University of Edinburgh, Scotland. "Cannabanoids inhibit excitatory responses of supraoptic neurons to stimulation of OVLT in vivo." * * *Arrangements for on-site interviews, or telephone interviews during the meeting, can be through APS from Mayer Resnick (cell: 301-332-4402; office 301-634-7209, or  mresnick the-aps.orgSponsorships. The American Physiological Society thanks the following sponsors for their generous support of the conference: Astellas Pharmaceuticals Inc., GlaxoSmithKline Pharmaceuticals, NIH/NIDDK, Wyeth Research and Olympus America Inc. Three APS Journals call for papers. In conjunction with the conference, three American Journal of Physiology (AJP) editions – AJP-Regulatory, Integrative and Comparative Physiology, AJP-Endocrinology and Metabolism, and AJP-Renal Physiology – have called for related papers for publication. The deadline for all editions is October 1, 2005. * * *The American Physiological Society was founded in 1887 to foster basic and applied bioscience. The Bethesda, Maryland-based society has more than 10,000 members and publishes 14 peer-reviewed journals containing almost 4,000 articles annually. APS provides a wide range of research, educational and career support and programming to further the contributions of physiology to understanding the mechanisms of diseased and healthy states. In May 2004, APS received the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring (PAESMEM). Complete Title: Endocannabinoids – The Brain's Cannabis – Demonstrate Novel Modes of Action To StressMayer Resnick Contact: mresnick the-aps.org301-634-7209 (office)301-332-4402 (cell)The American Physiological Society Source: EurekAlert (DC)Published: July 19, 2005Copyright: 2005 American Association for the Advancement of Science Contact: jsheehy psg.ucsf.eduWebsite: Medical Marijuana Archives

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Comment #2 posted by Jim Lunsford on July 19, 2005 at 09:17:27 PT
This might help explain why people who are experiencing the feelings of euphoria from their spiritual sacrament are so famously non-violent in their behavior. Perhaps the cannabinoids are inhibiting such stressors and allowing us to experience the flow of life without the pain attachments create in our psyche. No Buddhist influence in my life! lol  Also, since Jesus was anointed, does that mean the ONDCP is Satan's headquarters? Personally, I believe that good will overcome evil and that soon we will all be able to enjoy the fruit of God's creation, instead of suffering under man's quest to be greater than God with our synthetic lives (pharmaceutical companies, oil, etc.).Peace to all, and thanks,Reverend Jim
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Comment #1 posted by jose melendez on July 19, 2005 at 04:55:36 PT
news flash
[satire type=weak]Upon hearing word that cannabinoids do in fact have important medical properties, John Walters' and Joyce Nalepka's hypothalamuses simultaneously combusted. Andrea Barthwell was heard to say, "As a paid flip-flopper and NORML member, I've always known marijuana had important medical properties, and think every young pot smoker should be jailed for daring to feel better." Poppy coughed, and smiled at Dick, who can now belch the entire alphabet on command, and would really like some TUMS.[/satire]
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