Marijuana Firmly Linked to Infertility |
Posted by FoM on December 12, 2000 at 08:14:28 PT By Kristin Leutwyler Source: Scientific American Scientists from the University of Buffalo have smoked out what may cause some cases of infertility: marijuana. Today at the annual meeting of the American Society for Cell Biology, Herbert Schuel and his colleagues describe a cellular signaling system that responds to THC--the active substance in marijuana--and that may regulate sperm functions necessary for normal egg fertilization. The signaling system may be activated by anandamide, a cannabinoid-like molecule which this study shows for the first time is found in human seminal plasma, mid-cycle oviductal fluid and follicular fluid. "These findings suggest that defects in the cannabinoid receptor-signaling system could account for certain types of infertility," Schuel says. "A better understanding of these mechanisms might lead to the development of novel drugs useful in reproductive medicine. For heavy marijuana users, the study results raise the possibility they are jeopardizing fertility by overloading this system." To be sure, the process by which sperm prepare to fertilize an egg in the female reproductive tract is still mysterious. They must first become "capacitated" before they can begin swimming vigorously towards an egg and secrete the enzymes necessary to penetrate the egg's protective coat, a process called the acrosome reaction. But Schuel's work shows that both AM-356--a synthetic version of natural anandamide--and THC affect this sequence of events in three distinct ways: first, although low amounts of AM-356 stimulate sperm to swim more vigorously, too much of it has the exact opposite effect. Both AM-356 and TCH inhibit structural changes over the acrosome. And AM-356 significantly impairs sperm from binding to an egg's protective coat. "The increased load of cannabinoids in people who abuse marijuana could flood natural endocannabinoid-signal systems in reproductive organs and adversely impact fertility," Schuel adds. "This possibility may explain observations made over the past 30 to 40 years that marijuana smoke drastically reduces sperm production in males." Source: Scientific American (US) CannabisNews Medical Marijuana Archives Home Comment Email Register Recent Comments Help |
Comment #21 posted by na on January 20, 2002 at 14:22:09 PT |
Hard to believe! I know men who have been smoking a quarter a day since 13. Also women who are frequent users. They all have at least one child. One the heaviest user has several maybe 10 (he's not sure how many are out there) his wife is expecting twins, and already has one child with her. Another one has two children. I think this study needs to be re-done. There are problably other factors contributing to the thc infertility or other causes causing infertility.
I don't smoke weed, my boyfriend smokes very little and we have been trying to get pregnant for almost two years. We were unsuccessful once (miscarriage). How is it the heavy users can have kids but the non-users or little use users have infertility problems? Let's see a study done on this?
I WANT A CHILD!!!!!!!!!!!!!!!!!!!!!!!!!
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Comment #20 posted by skeezix on December 18, 2000 at 05:07:58 PT |
I like the last comment(#19). "I cant figure it out man....I smoked about a pound a month for the last 4 years,and she still got pregnant.Maybe there was something wrong with the study I read about.That guy Herbert Schuel burned me." [ Post Comment ] |
Comment #19 posted by Anonymous on December 18, 2000 at 04:32:11 PT |
Bad idea to let these lies get out. Watch the teen birth rate go up once this becomes "fact". [ Post Comment ] |
Comment #18 posted by dddd on December 13, 2000 at 12:18:09 PT |
Herbert Schuel Firmly Linked to Idiocy [ Post Comment ] |
Comment #17 posted by Maleksalem on December 13, 2000 at 11:06:26 PT:
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This month the prestigious Crock-O-Crap award goes to the "Scientists?" at the University of Buffalo. [ Post Comment ] |
Comment #16 posted by Curendero on December 12, 2000 at 18:36:47 PT:
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I heard long ago that pot was a great method of birth control.....First roll up the doob... then have her sit down on a chair and place it tightly between her knees!.....works every time....LOL,..sorry.. [ Post Comment ] |
Comment #15 posted by freedom fighter on December 12, 2000 at 17:32:31 PT |
Real Science! Factual! Gawd! If it was not for the herb, I am not so sure if my ex-wife would had a child with me. My son seemed so fine to me. And if they are talking about 9 more, geez! [ Post Comment ] |
Comment #14 posted by observer on December 12, 2000 at 14:58:19 PT |
I seem to remember a flap when Schuel perennial reefer madness "research" reared its ugly political head in 1998. The flap involved the hiding of the fact that NIDA funded this clown, but that the propaganda "news" releases `just accidently forgot' (innocent omission, you see) to mention that Schuel is funded by NIDA.
from the US Governments' 1999 IOM Report -- Doesn't marijuana cause fertility problems? Myth: Marijuana causes sterility and lowers testosterone and finally... Cannabis used in worship of Shinto fertility goddess -- [ Post Comment ] |
Comment #13 posted by FoM on December 12, 2000 at 14:04:52 PT:
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Pete W that was very well said. I hope it get's published. [ Post Comment ] |
Comment #12 posted by Pete W (UK) on December 12, 2000 at 13:40:24 PT |
I fired the following letter off to them: RE: CANNABIS CAN HALT 'FERTILITY SIGNALS' I read with great interest David Derbyshire's report claiming that cannabis users may be lowering their chances of having children (11 December 2000). Researchers, particularly in the United States, have been making these sensationalist claims regarding the effects on cannabis on sex hormones and reproduction since the early 1970's when it was claimed that cannabis caused male adolescents to grow breasts! [ Post Comment ] |
Comment #11 posted by ras james RSIFWH on December 12, 2000 at 12:45:13 PT |
Comment #10 posted by Smokeless in Seattle on December 12, 2000 at 12:20:25 PT |
Comment #9 posted by cryote on December 12, 2000 at 12:17:17 PT |
It has occurred to me that since many women suffer from
severe
morning sickness while pregnant, and since cannabis is
perhaps the
most effective anti-nauseant known, using the herb might
allow
pregnant women to better nourish themselves possibly
improving the
health of their children. Yet women in this country often
cease
smoking marijuana when they become pregnant, because they
do
not feel enough is known about what effects the herb may
have on
their child.
Despite the prevalence of marijuana smoking among women of
child-bearing age, few behavioral studies have been
performed to
date on babies whose mothers smoke, and these are
conflicting and
inconclusive in their findings.* Studies have been plagued
by
inconsistencies in measuring techniques and difficulty in
controlling
possible confounding effects of factors that could lead to
differences
in newborn behavior, such as multiple drug use, nutrition,
age and
socioeconomic status. Furthermore, the illegal status of
marijuana
makes self-reporting data suspect.
A March of Dimes sponsored study recently published in the
journal
Pediatrics is remarkable in several ways and emphasizes the
need
for further studies. The researchers were the first to use
seven
supplementary items on the Brazelton Neonatal Assessment
Scale in
a study of the effects of in utero drug exposure, possibly
measuring
for more subtle effects than previous studies. They
conducted their
research in Jamaica, making theirs the first such study
done outside
of the United States and Canada. The researchers noted that
while
in the U.S. and Canada marijuana use is mainly
recreational,
"scientific reports have documented the cultural
integration of
marijuana and its ritual and medicinal as well as
recreational
functions." The mothers studied were mainly the so-called
"Roots
Daughters," a relatively new group described as women with
a
purpose who can "think, reason and smoke like a man."
Self-reliant
and dignified, many of these women smoke on a daily basis
and
continue to do so during pregnancy and breast-feeding.
The study tested 24 Jamaican newborns exposed to marijuana
prenatally and 20 nonexposed babies from socioeconomically
matched mothers. The babies were compared when one day,
three
days and one month old by a Harvard-trained examiner who
was
unaware which babies had mothers who smoked.
The results at one day were thrown out because of
differences in
birth times, and the researchers found no significant
differences on
day three. At one month, the children of marijuana-using
mothers
scored markedly higher on autonomic stability, reflexes,
and general
irritability. Babies born to the heaviest smokers (those
who smoked
every day, at least 21 joints weekly) scored significantly
higher in 10
of the 14 characteristics measured, including quality of
alertness,
robustness, regulatory capacity, and orientation.
Even accounting for factors such as a higher level of
education and
more adults per child in the heavy-marijuana-smoking
mothers'
cases, these results are highly significant. No ill effects
from
marijuana were found, and quite possibly there were
dose-related
positive effects. The researchers recognize the preliminary
nature of
the study, but go so far as to speculate that, "It is
possible ... that the
outcomes at one month are related to neonatal exposure to
marijuana constituents via breast milk.
Nineteen of the 24 Jamaican mothers reported that cannabis
increased their appetites throughout the prenatal period
and/or
relieved the nausea of pregnancy. Fifteen reported using it
to relieve
fatigue and provide rest during pregnancy. It is also
possible that
these positive effects were responsible for their
developmentally
superior babies.
It is significant that these superior children were born in
an
atmosphere of acceptance and reverence for the herb.
Unfortunately, this is seldom the case in this country.
A law is on the books which would allow the Attorney
General of
California to distribute confiscated marijuana to
researchers, and this
step should be taken immediately. We must further demand an
end
to the persecution of our people, so that we and our
children may
flourish in an atmosphere of tolerance, understanding and
peace.
http://www.ukcia.org/medical/e_komp.html
Comment #8 posted by Colleen Furlong on December 12, 2000 at 11:52:33 PT |
Comment #7 posted by defenderoffreeworld on December 12, 2000 at 11:31:06 PT:
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Comment #6 posted by JR Bob Dobbs on December 12, 2000 at 10:26:09 PT |
Reminds me, obliquely, of Hitler's plans of sterilization. Sure, he wanted to kill undesirables, but sterilization was the next best option. I guess the prohibitionists are just hoping we're doing it to ourselves.
Which produces more cases of impotence - alcohol or marijuana? "It provokes the desire, but takes away the performance," to quote the porter from Macbeth on alcohol... lines written, quite possibly, by the world's most famous pothead...
Comment #5 posted by Ethan Russo, MD on December 12, 2000 at 09:54:44 PT:
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Comment #4 posted by Sudaca on December 12, 2000 at 09:18:35 PT |
Don't trade in your rubbers yet..
Comment #3 posted by FoM on December 12, 2000 at 09:13:25 PT |
Comment #2 posted by Morgan on December 12, 2000 at 09:11:23 PT |
And, after many years of partaking, I can safely say that it
hasn't kept my boys from swimming and finding their mark.
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Comment #1 posted by TroutMask on December 12, 2000 at 08:57:02 PT |
FYI, I would not recommend the "smoke a doobie" method of birth control. It has never worked for me.
-TM
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