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  Heavy Marijuana Use Damages Adolescent Brains
Posted by CN Staff on November 30, 2005 at 09:47:33 PT
By Reuters 
Source: Reuters 

cannabis Chicago -- Adolescents who regularly smoke marijuana risk damaging a key brain pathway associated with language development and some predisposed to schizophrenia may contract the illness early, researchers said on Wednesday.

Brain scans revealed microscopic abnormalities in a region of the brain that governs higher aspects of language and listening functions in adolescents who are heavy marijuana smokers.

Similar damage to the bundle of fibers, called the arcuate fasciculus, that connect the Broca's area in the left frontal lobe and the Wernicke's area in the left temporal lobe was found in the brains of marijuana smokers and schizophrenics studied.

"These findings suggest that in addition to interfering with normal brain development, heavy marijuana use in adolescents may also lead to an earlier onset of schizophrenia in individuals who are genetically predisposed to the disorder," said psychiatry professor Sanjiv Kumra of the Albert Einstein College of Medicine in New York.

The researchers scanned the brains of 114 subjects, 26 of whom were selected because they were diagnosed schizophrenics. Of the schizophrenic group, 15 smoked marijuana.

Another 15 subjects were nonschizophrenic adolescent male marijuana smokers who were matched against nonsmokers. It was those smokers whose scans showed abnormalities in the language and listening pathway.

The brain's language pathway continues to develop during adolescence and is susceptible to neurotoxins introduced through marijuana use, the researchers said.

A scanning technique called diffusion tensor imaging that detects and measures the motion of water molecules in the brain was used in the study, which was presented at the annual meeting of the Radiological Society of North America. The technique is not used to diagnose schizophrenia.

Roughly 3 million Americans aged 12 and older use marijuana on a daily or almost daily basis, according to the National Institute on Drug Abuse. The researchers said longer-term studies were needed to determine if the brain abnormalities observed in adolescents were permanent or not.

Source: Reuters (Wire)
Published: November 30, 2005
Copyright: 2005 Reuters

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Comment #23 posted by FoM on November 30, 2005 at 17:10:06 PT
What Actually Is A Normal Teenager?
When I think of a teenager I think of them as skitzy. I'm not being mean or anything just trying to make a point. Teenagers bounce from one emotion to another. They can be happy and laughing one minutes and angry and defiant the next. How could any teenagers be really analyzed correctly since they have such natural mood swings?

[ Post Comment ]
 
Comment #22 posted by FoM on November 30, 2005 at 16:31:56 PT
Siege
I used a related article and named you Newshawk. Thanks. I wonder what it really means? Does it mean people in the UK can have 4 ounces and it's OK? That would be great.

http://www.cannabisnews.com/news/thread21344.shtml

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Comment #21 posted by siege on November 30, 2005 at 16:04:01 PT
'Dealing' threshold will not help fight against dr
PRESS RELEASE Gillan: 'Dealing' threshold will not help fight against drugs Conservatives have criticised Government plans to set a threshold at which the amount of drugs a person is carrying goes from personal possession to dealing. The draft threshold is 4 ounces of cannabis, 10 ecstasy tablets or 7 grams of heroin or crack cocaine. Commenting, Shadow Home Affairs Minister Cheryl Gillan said:

http://www.conservatives.com/tile.do?def=news.press.release.page&obj_id=126615



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Comment #20 posted by siege on November 30, 2005 at 15:58:31 PT
New drugs limits to allow 500 'joints' for persona
New drugs limits to allow 500 'joints' for personal use

People caught by police with up to 500 cannabis joints on them are likely to escape drug dealing charges under new Home Office proposals. A joint being passed on 4oz of cannabis is enough to roll about 512 'joints'

Charles Clarke, the Home Secretary, revealed the plans to set a "threshold" for the amount of drugs an individual can claim is their own personal "stash".

Setting a formal limit will affect how many people can be prosecuted as drug dealers and how many escape with lesser charges.

http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2005/11/30/udrugs.xml&sSheet=/portal/2005/11/30/ixportaltop.html



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Comment #19 posted by Jim Lunsford on November 30, 2005 at 15:36:20 PT
Actually....
When this story first came out, the report stated that it was possible the teens using Cannabis were self-medicating. The use and the condition are not necessarily connected in the manner seen. It is quite possible that Cannabis is being utilized by the mind to heal itself. We do that all the time. Peace, Jim

Rev Jim Lunsford

First Cannabist Church

Thoughts: Our own, and in our complete control

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Comment #18 posted by Toker00 on November 30, 2005 at 15:34:06 PT
This PROVES nothing.
Blah, blah, blah...MAY contract the illness early,...blah, blah, blah.

Enough for any anti to immediately become a Believer.

"These findings suggest...No, ONDCP suggests you SUGGEST for propaganda purposes, these (suggested) findings.

Most of the "heavy" users, (and I doubt there are really that many teeny boppers who can afford to be a "heavy" cannabis user), smoke cigarettes, too. Could the neurotoxins be from the tobacco smoke? Just curious. And were the non-cannabis smokers "tobacco" free? I wonder. Because I don't think cannabis itself is toxic, but actually protects the neurotransmitters.

From FoM's article:...It is also important to mention that at this time, DTI and MRI are not diagnostic means for schizophrenia patients or marijuana smokers.

I got a problem with this. Would it also be important to mention, at this time, that you have proved nothing, except yourselves to be the "Albert Einstein College of Medicine in New York" who bends from pressure from DEA, ONDCP, etc., etc., to keep spewing propaganda about Cannabis? They are saying: "We want you to believe this though we know we can't prove it. But we will suggest it so we can keep the lid on Cannabis Liberalization. Those damn Hippies make our job of telling believable lies harder and harder.

Wage peace on war. END CANNABIS PROHIBITION NOW!



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Comment #17 posted by mars on November 30, 2005 at 15:29:51 PT:

re: A Fair Study
good point FoM.. let's start with Carl Sagan...

[ Post Comment ]
 
Comment #16 posted by charmed quark on November 30, 2005 at 15:27:01 PT
Daily users are an unusual subpopulation
As mentioned earlier, adolescents who are daily users are a very atypical subpopulation. Once again, assuming the imaging techniques are valid, correlation does not prove causation.

There may be an underlying brain difference or disorder that makes certain subgroups more likely to be daily users, perhaps as a form of self-medication. Additionally, most heavy users of cannabis also use other drugs, especially alchohol. Did the study try to eliminate these confounders?

The schizophrenic link has been knocked around for a while. It's possible there is a slight link to heavy cannabis users developing it earlier than they would have if they didn't use it. Of course, this could be another case of the early developers using cannabis to self medicate. It's hard to tell the cart from the horse You'd need a twin study to really resolve this - maybe one has been done. And, of course, there is no indication that it causes schizophrenia, as the rate is pretty consistent worldwide regardless of any factor.

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Comment #15 posted by FoM on November 30, 2005 at 15:07:31 PT
A Fair Study
Someone or some organization important in the government should ask people who have used Cannabis over many years certain questions and publish the results and use the published results to change the current laws. It is so simple to me. They never ask people that can answer honestly.

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Comment #14 posted by dongenero on November 30, 2005 at 14:54:53 PT
or.......
HealthDay News -- When it comes to the controversy surrounding medical marijuana, an international team of researchers is busy stirring the pot by releasing findings that suggest the drug helps promote brain cell growth while treating mood disorders.

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Comment #13 posted by Celaya on November 30, 2005 at 14:50:52 PT
More Smoke And Mirrors
That significant brain language development takes place in the teenage years is debatable, and the caveat thrown in at the end stating it is not known if the abnomalities are permanent or not makes the study even more nebulous. Throwing in data on schizophrenia clouds the issue to a huge degree as well.

The big question is how much would heavy alcohol use affect adolescent development. My guess is by a much greater and permanent degree.

And what is the point of citing the numbers of Americans 12 and older who use marijuana daily? 12 to 16 might be relevant, but including adults betrays a cynical attempt to pump the numbers for the relevance of this study.

These points must be taken into account as we will undoubtedly see this study cited as support for marijuana prohibition.

[ Post Comment ]

 
Comment #12 posted by billos on November 30, 2005 at 14:31:20 PT
Ekim?
Why did you mention the wizzinator being a felony to possess? I failed to see your link???

[ Post Comment ]
 
Comment #11 posted by ekim on November 30, 2005 at 14:17:59 PT
is a wizanator a felony just to have
i agree E.

what have these unjust laws created in our brains. how are we damaged by just waiting for the hammer to fall/



[ Post Comment ]
 
Comment #10 posted by siege on November 30, 2005 at 14:00:20 PT
still flawed
psychiatry professor Sanjiv Kumra; Where did your base line Start? did you have subjects from 1920 or 1937 to work with in this, That had Hemp to eat, ((hemp missing link)) anything before 2005. If your studys only have 2003 to 2005 you can not do a complete study of the science. It just shows the second out come of the study. So it is one sided study, or a government study that is flawed any way you look at it.

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Comment #9 posted by E_Johnson on November 30, 2005 at 12:56:49 PT
How did they control for PTSD and dissociation?
The teens most likely to be heavy users of marijuana are probably the ones who are suffering from the same kinds of problems that drive combat veterans and people in active combat to use it.

Post traumatic stress and dissociation are associated with damage to the brain especially to the brains of young people.

So how did they know for sure that this is not just another episode of confusing causation with correlation?

I know that most people in science come from sheletered upper middle class backgrounds and don't really understand that a vast percentage of young people in this country are in effect "walking wounded" from the damages of things like domestic violence and or sexual exploitation.

I was the walking wounded as an adolescent. I was so post traumatic I could not sleep at night, only in the daytime. And I was so dissociative it was hard to have a conversation with me because I'd blank out in the middle and lose my whole sense of self completely and just stare off into space.

It sure wasn't pot that did that -- I was that way before I ever tried pot, and I used pot to relieve my disociation -- but I can well imagine, especially given the sheltered, pampered backgrounds of many people in science-- that a scientist working for the government might have argued that marijuana did this to me.

The missing link in the study of adolescent marijuana use is PTSD. PTSD and dissociation. I'll bet that teens who are the heavist users are ones whose brains were fried at home by violent or sexually abusive adults living in their home under the name "family".

This subject is never going to be understood properly unless drug researchers are willing to recognize that about a quarter of the young people in this country have been ireperably damaged by their home life, and account for this fact when they do their research.

But it's very politically dangerous to admit that a large fraction of American parents are toxic to their own children.

Since it's the parents and not their victims who vote.



[ Post Comment ]

 
Comment #8 posted by PainWithNoInsurance on November 30, 2005 at 12:43:35 PT
Merit or Not
This study does not take into consideration the possibility that these conditions where already there and the teens where just born with them. I believe there is a reason for everything and a reason human beings seek drugs and alcohol. I know many people who absolutly cannot start their day without a buzz of coffee. I also know many people who don't drink coffee at all. It is the same with alcohol, some people drink it and some don't. I think the people who drink it are drinking because they are seeking to satify something that is not correct in their lives (physically or Mentally) and the same with caffeine.

Even if this study where absolutely true, it would not justify the punishment the government has put on people for using cannabis.

I think a study should be done to find out why some politicians have such cruel minds and some don't because cruelty is not normal human activity.

This study would need to be done with more subjects and a "before and after" use of cannabis before I would give it merit.

If my life where absolutely perfect, I would not want any caffeine, alcohol, prescription drugs, or illicit drugs.

[ Post Comment ]

 
Comment #7 posted by Hope on November 30, 2005 at 10:44:34 PT
Something to remember...
It hasn't been that long in the scheme of things, since potatoes and tomatoes were said, by supposedly those in the know, to be deadly poisonous.

[ Post Comment ]
 
Comment #6 posted by Hope on November 30, 2005 at 10:38:08 PT
Guess they didn't know about all
those deformed by pollution frog's parents sitting on their lilly pads toking joints that would eventually show up.

[ Post Comment ]
 
Comment #5 posted by Hope on November 30, 2005 at 10:33:08 PT
Remember the "science"
that told us it turned the brain of twenty somethings into the brains of ninety somethings? Or the one about the boy's brain that disintegrated like ash at an autopsy because of his marijuana use? Or the "science" that says it's use will give men big female breasts and women excess hair? Mustn't forget the "scientists" that told us it would scramble user's chromosones and deform their offspring. (They probably foresaw the problems from all the dangerous but profitable herbicides, insecticides, and pollutions on people and were setting up cannabis and certain "forbidden" drug use to take the blame.) Of course, we mustn't forget Anslinger's "scientist" who testified cannabis turned him into a bat.

Furthermore, I think I'm seeing another pattern being developed here. The pharms are working on real cannabis is "bad bad bad" while synthetic compounds copying certain cannabinoids are "good good good".

Makes me want to cuss.

[ Post Comment ]

 
Comment #4 posted by runruff on November 30, 2005 at 10:13:52 PT:

Here we go again, Jabber, jabber, jabber....
What does prescription drugs do to the adolecent brain? What does the legal drug alcohol do to the adolecent brain. What does TV, video games, refined sugar, do to the adolescent brain? I suggest that any parent that doesn't want their kids involved in these things teach them to abstain. It ain't my yob man! And neither does this finding if it has any validity have any detemination on my rights as a free adult to choose or anyone to choose cannabis for recreation or cannabis as a medicine. If we are complaining about child rearing problems here then this is a situation best delt with by the childs family not the prohibition of my right to choose what is best for me.

[ Post Comment ]
 
Comment #3 posted by potpal on November 30, 2005 at 10:11:09 PT
here we go again
Main stream media has no qualms jumping on a story planted like this one. Harry lives.

Such bullsh*t.

Wonder what 'heavy use' of sugar does to the adolecent brain? Have another 20oz coke, kids.

[ Post Comment ]

 
Comment #2 posted by FoM on November 30, 2005 at 10:03:36 PT
Related Article from PRNewswire
Press Release Source: Radiological Society of North America

Imaging Shows Similarities in Brains of Marijuana Smokers, Schizophrenics

Wednesday November 30, 2005

CHICAGO, Nov. 30 /PRNewswire/ -- Heavy use of marijuana may put adolescents who are genetically predisposed to schizophrenia at greater risk of developing the brain disorder, according to research presented today at the annual meeting of the Radiological Society of North America (RSNA).

Using a sophisticated brain imaging technique called diffusion tensor imaging (DTI), researchers at Zucker Hillside Hospital in Glen Oaks, New York, studied the brains of groups of adolescents: healthy, non-drug users; heavy marijuana smokers (daily use for at least one year); and schizophrenic patients. Unlike magnetic resonance imaging (MRI), which provides a static picture of brain structures, DTI detects and measures the motion of water molecules in the brain, which can reveal microscopic abnormalities.

Manzar Ashtari, Ph.D., Sanjiv Kumra, M.D., and colleagues used DTI to examine the arcuate fasciculus, a bundle of fibers connecting the Broca's area in the left frontal lobe and the Wernicke's area in the left temporal lobe of the brain. The investigators found that repeated exposure to marijuana was related to abnormalities in the development of this fiber pathway, which is associated with the higher aspects of language and auditory functions.

"Because this language/auditory pathway continues to develop during adolescence, it is most susceptible to the neurotoxins introduced into the body through marijuana use," explained Dr. Ashtari, associate professor of radiology and psychiatry at New York's Albert Einstein College of Medicine.

In the study, DTI was performed on 12 healthy, early adolescent males compared with 12 late adolescent males to show normal human brain development; 11 schizophrenic patients compared with 17 matched controls; 15 schizophrenic patients who smoke marijuana compared with 17 matched controls; and 15 marijuana smokers compared with 15 matched non-drug users. The scans revealed no abnormal developmental changes in the language pathway in the healthy adolescents, but showed abnormalities in both the marijuana users and schizophrenic patients.

"These findings suggest that in addition to interfering with normal brain development, heavy marijuana use in adolescents may also lead to an earlier onset of schizophrenia in individuals who are genetically predisposed to the disorder," said co-principal-investigator Sanjiv Kumra, M.D., assistant professor of psychiatry at Albert Einstein College of Medicine.

According to the National Institute on Drug Abuse, approximately 3.1 million Americans age 12 and older use marijuana on a daily or almost daily basis. In 2004, 5.6 percent of 12th graders reported daily use of marijuana.

Schizophrenia is a chronic, severe and disabling brain disorder that affects about one percent of the entire population. Although the causes of the disease have not been determined, it is believed to result from a combination of environmental and genetic factors.

Drs. Ashtari and Kumra said longitudinal studies are needed to determine whether these changes in the brain are permanent or change over time. It is also important to mention that at this time, DTI and MRI are not diagnostic means for schizophrenia patients or marijuana smokers.

Co-authors are Jinghui Wu, B.S., Kelly Cervellione, M.A., John Kane, M.D., Philip Szeszko, Ph.D., and Babak Ardekani, Ph.D.

RSNA is an association of more than 38,000 radiologists, radiation oncologists, medical physicists and related scientists committed to promoting excellence in radiology through education and by fostering research, with the ultimate goal of improving patient care. The Society is based in Oak Brook, Ill.

AT A GLANCE

-- Researchers using diffusion tensor imaging (DTI) have found similar abnormalities in the brains of adolescents who are daily marijuana users and adolescents with schizophrenia.

-- The abnormalities were found in a part of the brain still developing during adolescence that is associated with the higher aspects of language and auditory functions.

-- The findings also suggest that heavy use of marijuana may lead to earlier onset of schizophrenia in adolescents who are genetically predisposed to the disorder.

Source: Radiological Society of North America

http://biz.yahoo.com/prnews/051130/cgw007a.html?.v=2

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Comment #1 posted by dongenero on November 30, 2005 at 09:55:28 PT
I'll see your........
Albert Einstein College of Medicine findings and raise you one...............neuroprotective finding.

An earlier study published in the Journal of Neuroscience showed that synthetic cannabinoids, the chemicals in marijuana, can reduce inflammation in the brain and may protect it from the cognitive decline associated with Alzheimer's disease.

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